Diabetics with neuropathy have seven fold increased risk of foot ulcerations. Diabetics are also exposed to 15 fold higher risk of amputation of lower extremities compared to the general population. Vibration perception has been shown to be strongly associated with foot ulceration. VPT determination by using a Biothesiometer has been used to identify peripheral sensory neuropathy and subjects at risk of foot ulcerations.
Biothesiometry, a rapid, portable, and sensitive method of assessing VPTs, has been used on adolescents and adults to identify subclinical neuropathy and to monitor the progress of the disease. In adulthood, VPTs have been shown to be affected by increasing age and to be dependent on height.
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